Guanciale vs. Pancetta. Guanciale really lends a rich flavor to the dish, and has a melt-in-your-mouth texture and stronger flavor than pancetta. If you go with pancetta, the past will still be AMAZING, and it's much easier to find in whole or pre-cubed varieties in your local supermarket. The real difference is in the fat content, since both varieties come from different cuts of pork. Guanciale is a bolder flavor, while Pancetta is a bit on the milder side (and made with pork belly, rather than pork jowl).